Description

Triethyl α-Propargylphosphonoacetate is a specialized organophosphorus compound that serves as a versatile building block in advanced organic synthesis. Its unique structure, featuring both a propargyl and a phosphonoacetate group, makes it a critical reagent for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring propargyl or phosphonate functionalities.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its reactive groups enable the creation of potent active ingredients.
• Material Science Research: Employed in the development of specialty polymers and functional materials, including flame retardants and metal-chelating agents.
• Organic Synthesis Reagent: Acts as a Michael acceptor and a precursor for Horner-Wadsworth-Emmons (HWE) olefination reactions to form α,β-unsaturated esters.
• Ligand Precursor: Serves as a starting material for synthesizing specialized phosphonate-based ligands used in catalysis and metal complexation.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and bio-conjugation reagents due to its reactive alkyne group.

Basic Information

Product Name	Triethyl α-Propargylphosphonoacetate
CAS No.	26199-74-6
Molecular Formula	C₁₁H₁₉O₅P
Molecular Weight	262.24 g/mol
Synonyms	Triethyl (2-Propargyl)-2-phosphonoacetate; (2-Propargyl)-2-phosphonoacetic Acid Triethyl Ester; Triethyl 2-(Prop-2-yn-1-yl)-2-phosphonoacetate; Propargylphosphonoacetic Acid Triethyl Ester; α-Propargylphosphonoacetic Acid Triethyl Ester; Acetic acid, 2-(2-propynyl)-2-phosphono-, triethyl ester; Phosphonoacetic acid, α-propargyl-, triethyl ester
EINECS	Contact for details

Quality Control

Our Triethyl α-Propargylphosphonoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.