Description

Methyl o-Methyl-L-(+)-Mandelate is a chiral ester derivative of mandelic acid, serving as a high-value intermediate in fine chemical synthesis. Its primary commercial value lies in its utility as a key building block for the production of optically active pharmaceuticals and agrochemicals. This compound is particularly relevant for research and manufacturing chemists in the pharmaceutical, flavor & fragrance, and advanced material sectors who require enantiomerically pure intermediates for complex syntheses.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Asymmetric Synthesis: Used as a starting material or resolving agent in stereoselective reactions to construct complex molecules with defined chirality.
• Agrochemical Development: Serves as a precursor in the manufacture of chiral pesticides and herbicides, where specific stereochemistry is essential for bioactivity.
• Flavor and Fragrance Industry: Employed in the synthesis of enantiomerically pure aroma chemicals and flavoring agents.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and catalysis research within university and corporate laboratories.
• Liquid Crystal and Advanced Material Precursor: Can be utilized in the synthesis of chiral dopants for liquid crystal displays (LCDs) and other functional materials.

Basic Information

Product Name	Methyl o-Methyl-L-(+)-Mandelate
CAS No.	26164-27-2
Molecular Formula	C11H14O4
Molecular Weight	210.23 g/mol
Synonyms	Methyl (R)-2-Methoxy-2-phenylacetate; (R)-(-)-Methyl 2-Methoxy-2-phenylacetate; L-(+)-Methyl o-Methylmandelate; (R)-2-Methoxy-2-phenylacetic acid methyl ester; Methyl (R)-α-methoxyphenylacetate; (R)-Methyl mandelate methyl ether; (2R)-2-Methoxy-2-phenylacetic acid methyl ester; o-Methyl-L-mandelic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl o-Methyl-L-(+)-Mandelate is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and IR spectroscopy for structural confirmation. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	+80° to +90° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.