Description

Dotefonium is a quaternary ammonium compound with anticholinergic and antispasmodic properties, widely recognized in the pharmaceutical industry. Its primary value lies in its efficacy as a smooth muscle relaxant, targeting specific receptors to alleviate spasms in the gastrointestinal and urinary tracts. This makes it a critical active pharmaceutical ingredient (API) for manufacturers developing medications to treat conditions like irritable bowel syndrome, biliary dyskinesia, and urinary incontinence. Global pharmaceutical and fine chemical suppliers require high-purity Dotefonium CAS NO 26058-50-4 to ensure the safety and efficacy of final drug formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in antispasmodic and anticholinergic drug formulations.
• Gastrointestinal Therapeutics: Manufacture of medications for treating irritable bowel syndrome (IBS), gastritis, and peptic ulcers.
• Urological Spasmolytics: Key component in drugs for urinary tract spasms, bladder overactivity, and renal colic.
• Biliary Tract Disorders: Used in formulations targeting biliary dyskinesia and gallstone-related pain.
• Research & Development: Serves as a reference standard and building block in pharmacological and medicinal chemistry research.
• Veterinary Medicine: Application in veterinary pharmaceuticals for treating visceral spasms in animals.

Basic Information

Product Name	Dotefonium
CAS No.	26058-50-4
Molecular Formula	C21H30BrNO3
Molecular Weight	424.38 g/mol
Synonyms	Dotefonium Bromide; 2-[(2,6-Dimethylphenyl)carbamoyloxy]-N,N-diethyl-N-methylethanaminium Bromide; Diethyl(2-hydroxyethyl)methylammonium Bromide 2,6-Dimethylphenylcarbamate; Difeterion; Difeterion Bromide; CAS 26058-50-4; UNII-3T5P8UQ96W
EINECS	Contact for details

Quality Control

Our Dotefonium is manufactured under strict quality management systems to meet the stringent requirements of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, ensuring compliance with ICH guidelines and relevant pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, purity, and consistency for your regulatory submissions and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.