Description

N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Methyl Ester CAS NO 25824-43-5 is a protected derivative of the essential amino acid L-lysine, featuring trimethylsilyl (TMS) groups on the amine functionalities. This compound is critically important as a key synthetic intermediate and protecting group reagent in advanced organic and peptide chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, bioactive molecules, and complex organic compounds where selective amine protection is required.

Application

• Peptide Synthesis Intermediate: Serves as a crucial building block for the solid-phase and solution-phase synthesis of complex peptides, protecting the lysine side chain during coupling reactions.
• Pharmaceutical Research & Development: Used in the discovery and scale-up of new active pharmaceutical ingredients (APIs), particularly those containing lysine residues.
• Bioconjugation Chemistry: Acts as a reagent for modifying biomolecules, enabling the site-specific attachment of labels, drugs, or other functional groups to proteins and antibodies.
• Organic Synthesis Reagent: Employed as a protecting group agent for primary amines in multi-step synthetic routes for complex natural products and specialty chemicals.
• Material Science Precursor: Utilized in the development of specialized silicon-containing polymers and advanced materials.

Basic Information

Product Name	N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Methyl Ester
CAS No.	25824-43-5
Molecular Formula	C15H36N2O2Si3
Molecular Weight	360.71 g/mol
Synonyms	L-Lysine, N2,N6,N6-tris(trimethylsilyl)-, methyl ester; Methyl N2,N6,N6-tris(trimethylsilyl)-L-lysinate; Nα,Nε,Nε-Tris(trimethylsilyl)-L-lysine methyl ester; TMS-Lys-OMe; (S)-Methyl 2,6-bis(trimethylsilylamino)hexanoate (Note: structure indicates three TMS groups); Lys(TMS)3-OMe; Protected L-Lysine Methyl Ester
EINECS	Contact for details

Quality Control

Our N2,N6,N6-Tris(Trimethylsilyl)-L-Lysine Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.