Description

Methyl 3-Isocyanatothiophene-2-Carboxylate (Saltdata: Free) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound matters as a versatile precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for introducing the thiophene-isocyanate moiety into target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides with thiophene-based active ingredients.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with unique thermal or electronic properties.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology: Useful as a probe or labeling reagent for bioconjugation due to its reactive isocyanate group.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	Methyl 3-Isocyanatothiophene-2-Carboxylate (Saltdata: Free)
CAS No.	25712-16-7
Molecular Formula	C7H5NO3S
Molecular Weight	183.18 g/mol
Synonyms	3-Isocyanato-2-thiophenecarboxylic acid methyl ester; Methyl 3-isocyanato-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 3-isocyanato-, methyl ester; Methyl 3-isocyanatothiophene-2-carboxylate; 3-Isocyanatothiophene-2-carboxylic acid methyl ester; Thiophene-2-carboxylic acid, 3-isocyanato-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Isocyanatothiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.