Description

N-(Trimethylsilyl)glycine methyl ester is a versatile organosilicon-protected amino acid derivative, essential for advanced organic synthesis. Its primary value lies in its role as a key synthetic intermediate, offering a protected glycine moiety that is stable under a wide range of reaction conditions. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of peptides, modified amino acids, and complex organic molecules.

Application

• Peptide Synthesis Intermediate: Serves as a protected glycine building block in solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Organocatalyst and Ligand Precursor: Used in the preparation of novel silicon-containing catalysts and ligands for asymmetric synthesis.
• Agrochemical Active Ingredient Synthesis: A key intermediate in the manufacturing of advanced herbicides and plant growth regulators.
• Pharmaceutical Intermediate: Employed in the research and development of novel drug candidates, particularly those requiring modified amino acid backbones.
• Material Science Research: Utilized in the synthesis of functionalized silanes for surface modification and the creation of hybrid organic-inorganic materials.
• Chemical Biology Probes: Acts as a starting material for synthesizing labeled or tagged amino acids used in proteomics and metabolic studies.

Basic Information

Product Name	N-(Trimethylsilyl)glycine methyl ester
CAS No.	25688-72-6
Molecular Formula	C6H15NO2Si
Molecular Weight	161.28 g/mol
Synonyms	Methyl 2-[(trimethylsilyl)amino]acetate; Glycine, N-(trimethylsilyl)-, methyl ester; Methyl N-(trimethylsilyl)glycinate; Trimethylsilylglycine methyl ester; N-(Trimethylsilyl)-glycine methyl ester; N-TMS-glycine-OMe; N-Trimethylsilylglycine methyl ester
EINECS	Contact for details

Quality Control

Our N-(Trimethylsilyl)glycine methyl ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.