Description

Ethyl 4,4,4-Trifluorocrotonate is a high-value fluorinated building block, an ester of 4,4,4-trifluorocrotonic acid, essential for introducing the trifluoromethyl group into complex molecular architectures. Its primary commercial value lies in its role as a versatile Michael acceptor and synthon in the synthesis of advanced pharmaceutical intermediates and agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel fluorine-containing compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing the CF3 group, which improves metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the trifluoromethyl moiety enhances biological activity and environmental persistence.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with unique surface properties.
• Organic Synthesis Building Block: Employed in Michael addition reactions, cycloadditions, and other carbon-carbon bond-forming transformations to access complex fluorinated molecules.
• Liquid Crystal & OLED Materials: Acts as a starting material for synthesizing fluorinated components used in electronic displays and optoelectronic devices.

Basic Information

Product Name	Ethyl 4,4,4-Trifluorocrotonate
CAS No.	25597-16-4
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	Ethyl (E)-4,4,4-Trifluorobut-2-enoate; (E)-Ethyl 4,4,4-Trifluorocrotonate; 4,4,4-Trifluorocrotonic Acid Ethyl Ester; trans-Ethyl 4,4,4-Trifluorocrotonate; 2-Butenoic acid, 4,4,4-trifluoro-, ethyl ester, (E)-; Ethyl trans-4,4,4-Trifluorocrotonate; NSC 5185; Ethyl 4,4,4-Trifluoro-2-butenoate
EINECS	Contact for details

Quality Control

Our Ethyl 4,4,4-Trifluorocrotonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isomeric Purity (GC)	≥ 95.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.