Description

L-Asparagine tert-Butyl Ester is a protected amino acid derivative, specifically the tert-butyl ester of L-asparagine. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the L-asparagine moiety while providing orthogonal protection for the carboxylic acid group. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: A key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for constructing peptide chains containing L-asparagine.
• Pharmaceutical Research: Serves as a critical starting material or intermediate in the research and development of novel therapeutic agents, including enzyme inhibitors and receptor ligands.
• Bioconjugation Chemistry: Used in the preparation of modified peptides and protein conjugates for drug delivery systems and diagnostic probes.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Agrochemical Research: Acts as a synthetic intermediate in the development of new crop protection agents and bioactive compounds.

Basic Information

Product Name	L-Asparagine tert-Butyl Ester
CAS No.	25456-86-4
Molecular Formula	C9H18N2O4
Molecular Weight	218.25 g/mol
Synonyms	L-Asparagine tert-butyl ester; (S)-2-Amino-3-carbamoylpropanoic acid tert-butyl ester; tert-Butyl L-asparaginate; H-Asn-OtBu; Boc-Asn-OtBu (when referring to N-Boc protected variant); L-Asparagine O-tert-butyl ester; Asparagine tert-butyl ester; (S)-2-Amino-4-amino-4-oxobutanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our L-Asparagine tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements of pharmaceutical research and development. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other relevant specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.