Description

D-Glutamic Acid 1-tert-Butyl Ester is a protected amino acid derivative of significant importance in synthetic organic and peptide chemistry. This compound serves as a crucial chiral building block, enabling the controlled synthesis of complex molecules while preventing unwanted side reactions at the carboxylic acid group. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, prodrugs, and other bioactive compounds. The high purity and defined stereochemistry of this intermediate are essential for ensuring the success and reproducibility of advanced synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based therapeutics, prodrugs, and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-glutamic acid residues with a protected side chain, preventing racemization.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and for probing receptor-ligand interactions due to its specific stereochemistry.
• Asymmetric Synthesis: Serves as a starting material or intermediate in the asymmetric synthesis of more complex natural products and non-natural amino acids.
• Protecting Group Strategy: The tert-butyl ester group provides a base-labile protecting group that is stable under acidic conditions, facilitating multi-step synthetic sequences.

Basic Information

Product Name	D-Glutamic Acid 1-tert-Butyl Ester
CAS No.	25456-76-2
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	D-Glutamic Acid 1-tert-Butyl Ester; (R)-2-Amino-5-tert-butoxy-5-oxopentanoic Acid; D-Glu(OtBu)-OH; H-D-Glu(OtBu)-OH; tert-Butyl D-glutamate; D-Glutamic Acid γ-tert-Butyl Ester; (R)-4-(tert-Butoxy)-4-oxobutanoic Acid; D-2-Aminoglutaric Acid 1-tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our D-Glutamic Acid 1-tert-Butyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity determined by HPLC. A Certificate of Analysis (COA) detailing specific results for identity, assay, and impurities is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.