Description

2-Methyl-2-((Trimethylsilyl)Oxy)Butanenitrile is a versatile organosilicon-protected cyanohydrin derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its primary value lies in its ability to act as a masked acyl anion equivalent, enabling the controlled introduction of carbonyl functionalities under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for constructing complex molecular architectures and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially those requiring chiral centers or specific carbonyl group manipulations.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where its protected functional group allows for selective reactions.
• Fine Chemical Manufacturing: Employed in the synthesis of specialty chemicals, flavors, fragrances, and advanced materials.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry, particularly in studies involving cyanohydrin chemistry and silicon-based protecting groups.
• Peptide Mimetics: Useful in the preparation of non-peptidic scaffolds and constrained analogs for medicinal chemistry programs.

Basic Information

Product Name	2-Methyl-2-((Trimethylsilyl)Oxy)Butanenitrile
CAS No.	25438-34-0
Molecular Formula	C8H17NOSi
Molecular Weight	171.31 g/mol
Synonyms	2-Methyl-2-(trimethylsiloxy)butyronitrile; Butanenitrile, 2-methyl-2-[(trimethylsilyl)oxy]-; α-(Trimethylsiloxy)isobutyronitrile; Trimethylsilyl 2-cyano-2-propyl ether; TMS-protected acetone cyanohydrin; 2-Cyano-2-propyloxytrimethylsilane; (1-Cyano-1-methylethoxy)trimethylsilane
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-((Trimethylsilyl)Oxy)Butanenitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.