Description

3-Pyridinecarboxylicacid,Trimethylsilylester(9Ci) is a trimethylsilyl-protected derivative of nicotinic acid, a key intermediate in organic synthesis and pharmaceutical research. This compound is valued for its role in protecting carboxylic acid groups, enabling complex multi-step synthetic sequences with high selectivity and yield. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active pharmaceutical ingredients (APIs), ligands, and functionalized heterocycles.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug molecules, particularly those containing pyridine or nicotinic acid pharmacophores.
• Agrochemical Synthesis: Used in the development of novel herbicides, insecticides, and fungicides that require protected carboxylic acid functionality.
• Organometallic Catalyst Ligand: Serves as a precursor for creating specialized ligands used in transition metal-catalyzed coupling reactions.
• Peptide & Polymer Chemistry: Employed as a protecting group reagent in the synthesis of modified peptides and specialty polymers.
• Material Science Research: Utilized in the development of organic semiconductors, metal-organic frameworks (MOFs), and other functional materials.
• Academic & R&D Laboratories: A standard reagent for methodological studies in synthetic organic chemistry and new reaction development.

Basic Information

Product Name	3-Pyridinecarboxylicacid,Trimethylsilylester(9Ci)
CAS No.	25436-37-7
Molecular Formula	C9H13NO2Si
Molecular Weight	195.29 g/mol
Synonyms	Nicotinic Acid Trimethylsilyl Ester; Trimethylsilyl Nicotinate; 3-(Trimethylsilyloxycarbonyl)pyridine; Pyridine-3-carboxylic Acid Trimethylsilyl Ester; TMS Nicotinate; 3-Carboxypyridine Trimethylsilyl Ester; 3-Pyridinecarboxylic Acid TMS Ester; 25436-37-7
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarboxylicacid,Trimethylsilylester(9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for critical research and production applications. Our quality assurance includes comprehensive analytical characterization to verify identity, purity, and stability. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and moisture content. We adhere to cGMP principles for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.