Description

2-Acetoxybenzoic Acid Trimethylsilyl Ester is a silylated derivative of acetylsalicylic acid, serving as a key protected intermediate in advanced organic synthesis. This compound is valued for its role in introducing the salicylate moiety under mild, non-acidic conditions, which is critical for protecting sensitive functional groups during complex reaction sequences. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of salicylate-based drug candidates and prodrugs, where protection of the carboxylic acid group is required.
• Organic Synthesis Reagent: Acts as a versatile building block for introducing the 2-acetoxybenzoyl group into complex molecules under mild conditions.
• Agrochemical Research: Employed in the development of new herbicides and plant growth regulators that incorporate modified salicylic acid structures.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with unique thermal or solubility properties.
• Analytical Reference Standard: Serves as a high-purity standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	2-Acetoxybenzoic Acid Trimethylsilyl Ester
CAS No.	25436-28-6
Molecular Formula	C₁₂H₁₆O₄Si
Molecular Weight	252.34 g/mol
Synonyms	Acetylsalicylic Acid Trimethylsilyl Ester; Aspirin TMS Ester; 2-(Acetyloxy)benzoic Acid Trimethylsilyl Ester; O-Acetylsalicylic Acid Trimethylsilyl Ester; TMS Aspirin; Trimethylsilyl Acetylsalicylate; [2-(Trimethylsilyloxycarbonyl)phenyl] Acetate; Salicylic Acid Acetate Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our 2-Acetoxybenzoic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.