Description

4-Chlorobenzoic Acid Trimethylsilyl Ester is a versatile organosilicon reagent and a key protected intermediate in synthetic organic chemistry. Its primary value lies in its role as a silylating agent and a masked carboxylic acid, facilitating complex multi-step syntheses where selective deprotection is required. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where the 4-chlorobenzoic acid moiety needs temporary protection from reactive conditions.
• Agrochemical Synthesis: Serves as a key precursor in the development of herbicides, fungicides, and other crop protection agents.
• Peptide Chemistry: Employed as a carboxyl-protecting group in peptide synthesis to prevent unwanted side reactions.
• Material Science Research: Acts as a monomer or modifying agent in the development of specialized polymers and organic electronic materials.
• Analytical Derivatization: Used to silylate compounds for Gas Chromatography (GC) or GC-Mass Spectrometry (GC-MS) analysis, improving volatility and detection.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.

Basic Information

Product Name	4-Chlorobenzoic Acid Trimethylsilyl Ester
CAS No.	25436-27-5
Molecular Formula	C10H13ClO2Si
Molecular Weight	228.75 g/mol
Synonyms	Trimethylsilyl 4-chlorobenzoate; p-Chlorobenzoic Acid Trimethylsilyl Ester; 4-Chlorobenzoic Acid TMS Ester; TMS 4-Chlorobenzoate; (4-Chlorobenzoyloxy)trimethylsilane; Benzoic acid, 4-chloro-, trimethylsilyl ester; Trimethyl(4-chlorobenzoyloxy)silane
EINECS	Contact for details

Quality Control

Our 4-Chlorobenzoic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere such as nitrogen or argon after opening to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.