Description

n-Acetylglycine Trimethylsilyl Ester is a protected derivative of the amino acid glycine, featuring both acetyl and trimethylsilyl (TMS) protecting groups. This compound is a crucial building block in organic synthesis, particularly in peptide chemistry, where it facilitates controlled reactions by masking reactive functional groups. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis Intermediate: Serves as a key protected glycine derivative for the solid-phase and solution-phase synthesis of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of new therapeutic agents, including enzyme inhibitors and receptor ligands.
• Bioconjugation Chemistry: Acts as a reagent for introducing modified glycine units into biomolecules like proteins or antibodies for drug delivery systems.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged amino acid analogs for studying biological processes and mechanisms.
• Material Science: Potential use as a monomer or precursor for specialized polymers and functional materials.
• Academic & Industrial Research: A valuable tool for synthetic chemists in methodology development and the construction of complex molecular architectures.

Basic Information

Product Name	n-Acetylglycine Trimethylsilyl Ester
CAS No.	25436-19-5
Molecular Formula	C7H15NO3Si
Molecular Weight	189.29 g/mol
Synonyms	N-Acetylglycine TMS Ester; N-Acetylglycine Trimethylsilyl Ester; Acetylglycine Trimethylsilyl Ester; (Trimethylsilyl) N-acetylglycinate; Glycine, N-acetyl-, trimethylsilyl ester; 2-(Acetylamino)acetic acid trimethylsilyl ester; TMS-N-Acetylglycinate
EINECS	Contact for details

Quality Control

Our n-Acetylglycine Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.