Description

11-Cis Retinoic Acid Methyl Ester is a specific geometric isomer of retinoic acid methyl ester, a key derivative in retinoid chemistry. This compound is valued for its precise stereochemistry, which is critical for research into visual cycle biochemistry and cellular signaling pathways. It serves as an essential advanced pharmaceutical intermediate and a high-purity reference standard for laboratories in the life sciences, pharmaceutical development, and advanced material synthesis sectors.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel retinoid-based therapeutics targeting dermatological conditions, oncology, and metabolic disorders.
• Biochemical Research: Used as a precise molecular probe to study the visual cycle, specifically the role of 11-cis-retinal in rhodopsin and photoreceptor function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, and other chromatographic systems.
• Cell Biology Studies: Employed in research on cellular differentiation, proliferation, and apoptosis mediated by retinoid signaling pathways.
• Cosmeceutical R&D: Investigated for potential applications in advanced skincare formulations targeting photoaging and cellular repair.
• Organic Synthesis: A valuable chiral synthon for constructing complex molecules with specific stereochemical requirements in medicinal chemistry.

Basic Information

Product Name	11-Cis Retinoic Acid Methyl Ester
CAS No.	25428-67-5
Molecular Formula	C21H30O2
Molecular Weight	314.46 g/mol
Synonyms	Methyl 11-cis-retinoate; 11-cis-Retinoic Acid Methyl Ester; (11Z)-Retinoic Acid Methyl Ester; 11-Z-Retinoic Acid Methyl Ester; Vitamin A Acid Methyl Ester (11-cis-); all-trans-Retinoic Acid Methyl Ester Isomer; Methyl (2E,4E,6E,8E,10E,12Z,14E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8,10,12,14-heptaenoate
EINECS	Contact for details

Quality Control

Our 11-Cis Retinoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isomer specificity, to ensure it meets the exacting standards required for research and synthesis. Certificates of Analysis (COA) documenting identity, purity, and isomer content are available for every lot. We support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is strictly light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area Percent)
Isomeric Purity (11-cis-)	≥ 95.0% (by HPLC)
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Solvent Residue (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.