Description

Cycloguanil Nitrate CAS NO 25332-44-9 is a synthetic organic compound belonging to the class of biguanide derivatives. It serves as a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of antimalarial and antiprotozoal agents. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing treatments for parasitic diseases.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the active component in antimalarial drug formulations.
• Chemical Intermediate: Key building block in the synthesis of more complex dihydrofolate reductase (DHFR) inhibitors.
• Pharmaceutical Research: Used in biochemical and pharmacological studies targeting protozoan parasites like *Plasmodium* species.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and validation.
• Veterinary Medicine: Potential application in the development of antiparasitic treatments for animals.

Basic Information

Product Name	Cycloguanil Nitrate
CAS No.	25332-44-9
Molecular Formula	C11H15N7 • HNO3
Molecular Weight	309.30 g/mol
Synonyms	Cycloguanil Mononitrate; 1-(p-Chlorophenyl)-5-isopropylbiguamide Nitrate; 1-(4-Chlorophenyl)-5-isopropylbiguamide Nitrate; NSC-32968; WR 38839; Chloroguanide Triazine Metabolite Nitrate; Proguanil Metabolite Nitrate
EINECS	Contact for details

Quality Control

Our Cycloguanil Nitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.