Description

Thiofluorescein is a sulfur-containing derivative of fluorescein, a key organic compound used as a versatile building block and precursor in advanced chemical synthesis. Its unique structure makes it valuable for developing fluorescent probes, sensors, and specialized dyes with tailored photophysical properties. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require reliable, high-quality materials for sensitive applications.

Application

• Fluorescent Probe Synthesis: A critical precursor for creating thiol-reactive fluorescent labels and tags used in bioimaging and cellular staining.
• Bioconjugation Chemistry: Used in the development of conjugates for labeling proteins, antibodies, and other biomolecules.
• Sensor Development: Serves as a key intermediate in the manufacture of chemical sensors and indicators for detecting metal ions or specific analytes.
• Dye and Pigment Manufacturing: Acts as a specialized intermediate for producing xanthene-based dyes with modified spectral properties.
• Pharmaceutical Research: Employed in the synthesis of drug candidates and diagnostic agents where a fluorescein scaffold is required.
• Material Science: Used in the development of advanced polymeric materials and coatings with fluorescent characteristics.

Basic Information

Product Name	Thiofluorescein
CAS No.	25319-73-7
Molecular Formula	C20H12O5S
Molecular Weight	364.37 g/mol
Synonyms	9-(2-Carboxyphenyl)-6-hydroxy-3H-xanthene-3-thione; 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzenecarbothioic acid; Thiofluoresceine; Fluorescein thioanhydride; Sulfur-substituted fluorescein; Thiofluorescein isomer; 3'-Thiofluorescein
EINECS	Contact for details

Quality Control

Our Thiofluorescein is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profile. We are committed to meeting the exacting standards required for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.