Description

2,2,2-Trifluoroethyl Methanesulfonate is a versatile and highly reactive alkylating agent, specifically a methanesulfonate ester of 2,2,2-trifluoroethanol. Its primary value lies in its ability to efficiently introduce the 2,2,2-trifluoroethyl group into target molecules, a key modification for enhancing lipophilicity, metabolic stability, and biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and specialty fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, where the trifluoroethyl group modulates pharmacokinetic properties.
• Agrochemical Synthesis: Used to create fluorinated pesticides, herbicides, and fungicides, leveraging fluorine's ability to improve efficacy and environmental stability.
• Material Science: Building block for specialty polymers, liquid crystals, and advanced materials that require fluorinated segments for unique thermal, chemical, or surface properties.
• Organic Synthesis & Catalysis: Acts as an efficient alkylating agent in nucleophilic substitution reactions for introducing the -CH2CF3 moiety into complex organic frameworks.
• Radiochemistry & Diagnostics: Potential precursor for the synthesis of fluorinated tracers and probes used in Positron Emission Tomography (PET) imaging and other diagnostic applications.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various metal-catalyzed cross-coupling reactions to construct carbon-carbon bonds.

Basic Information

Product Name	2,2,2-Trifluoroethyl Methanesulfonate
CAS No.	25236-64-0
Molecular Formula	C3H5F3O3S
Molecular Weight	178.13 g/mol
Synonyms	2,2,2-Trifluoroethyl Methanesulfonate; 2,2,2-Trifluoroethyl Mesylate; Methanesulfonic Acid 2,2,2-Trifluoroethyl Ester; Trifluoroethyl Methanesulfonate; 2,2,2-Trifluoroethyl Methylsulfonate; α,α,α-Trifluoroethyl Methanesulfonate; TFEM; 2,2,2-Trifluoroethanol Methanesulfonate Ester
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethyl Methanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.5 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.