Description

Propionic Acid (3S)-1,3α-Dimethyl-4-Phenylpiperidine-4β-Yl Ester is a specialized chiral piperidine derivative ester with significant utility in advanced organic synthesis. This compound matters as a high-value pharmaceutical intermediate and a versatile chiral building block for constructing complex molecules with defined stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and analgesic drugs.
• Chiral Building Block: Used in asymmetric synthesis to introduce the (3S)-1,3α-dimethyl-4-phenylpiperidine moiety into target molecules, enabling the creation of enantiomerically pure compounds.
• Agrochemical Research: Serves as a starting material or intermediate in the development of new pesticides and herbicides with specific stereochemical requirements.
• Catalyst Ligand Synthesis: Employed in the preparation of novel chiral ligands for asymmetric catalysis and transition metal complexes.
• Medicinal Chemistry Research: Utilized in drug discovery programs for structure-activity relationship (SAR) studies and the preparation of compound libraries.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Propionic Acid (3S)-1,3α-Dimethyl-4-Phenylpiperidine-4β-Yl Ester
CAS No.	25123-06-2
Molecular Formula	C18H27NO2
Molecular Weight	289.41 g/mol
Synonyms	(3S)-1,3α-Dimethyl-4-phenyl-4β-piperidinyl propionate; 4β-[(2-Methylpropanoyl)oxy]-1,3α-dimethyl-4-phenylpiperidine; Propanoic acid, (3S)-1,3α-dimethyl-4-phenyl-4-piperidinyl ester; 1,3α-Dimethyl-4-phenyl-4β-piperidinol propionate (ester); (3S)-1,3α-Dimethyl-4-phenylpiperidin-4β-yl propanoate; 4-Phenyl-1,3α-dimethyl-4β-piperidinyl propionate
EINECS	Contact for details

Quality Control

Our Propionic Acid (3S)-1,3α-Dimethyl-4-Phenylpiperidine-4β-Yl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.