Description

[2S,3S,(-)]-2,3-Dihydro-2-(3-Hydroxy-4-Methoxyphenyl)-6-Methoxy-3-Methylbenzofuran-5-Ol is a high-purity chiral benzofuran derivative with significant potential in advanced organic synthesis and pharmaceutical research. This compound matters as a sophisticated building block for developing novel active pharmaceutical ingredients (APIs) and fine chemicals, where its specific stereochemistry is critical for biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and functional groups.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related compounds.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic Research: Applied in university and institutional labs for studying novel organic reactions, catalysis, and natural product synthesis.

Basic Information

Product Name	[2S,3S,(-)]-2,3-Dihydro-2-(3-Hydroxy-4-Methoxyphenyl)-6-Methoxy-3-Methylbenzofuran-5-Ol
CAS No.	25089-37-6
Molecular Formula	C₁₈H₂₀O₅
Molecular Weight	316.35 g/mol
Synonyms	(-)-2,3-Dihydro-2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-3-methyl-5-benzofuranol; (2S,3S)-2-(3-Hydroxy-4-methoxyphenyl)-6-methoxy-3-methyl-2,3-dihydrobenzofuran-5-ol; 2,3-Dihydro-2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-3-methylbenzofuran-5-ol; 25089-37-6; (2S,3S)-3-Methyl-2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-2,3-dihydrobenzofuran-5-ol
EINECS	Contact for details

Quality Control

Our [2S,3S,(-)]-2,3-Dihydro-2-(3-Hydroxy-4-Methoxyphenyl)-6-Methoxy-3-Methylbenzofuran-5-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. We support cGMP standards for pharmaceutical applications and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.