Description

3-[Bis(2-Chloroethyl)Amino]Phenylpiperidino Ketone is a specialized nitrogen mustard derivative with a piperidine ketone functional group, serving as a critical advanced intermediate in pharmaceutical research and development. Its molecular architecture makes it a valuable precursor for synthesizing targeted therapeutic agents, particularly in oncology and other specialized medicinal chemistry applications. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and fine chemical industries seeking to develop novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel nitrogen mustard-based chemotherapeutic agents and targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new alkylating agents.
• Bioconjugation & Prodrug Development: Serves as a reactive moiety for creating antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Chemical Biology Probes: Employed in the development of molecular probes to study DNA alkylation mechanisms and cellular repair pathways.
• Process Chemistry & Scale-up: Used in pilot plant and kilo-lab scale synthesis for clinical trial material (CTM) production.
• Academic & Institutional Research: A reagent for investigating new synthetic methodologies and the biological activity of nitrogen mustards.

Basic Information

Product Name	3-[Bis(2-Chloroethyl)Amino]Phenylpiperidino Ketone
CAS No.	24813-03-4
Molecular Formula	C16H22Cl2N2O
Molecular Weight	329.26 g/mol
Synonyms	1-[3-[Bis(2-chloroethyl)amino]phenyl]-1-piperidin-1-ylmethanone; 3-[Bis(2-chloroethyl)amino]-α-piperidinobenzyl ketone; 3-[Bis(2-chloroethyl)amino]phenyl piperidinyl ketone; 3-(Bis(2-chloroethyl)amino)phenyl(piperidin-1-yl)methanone; 1-(3-(Bis(2-chloroethyl)amino)phenyl)-1-(piperidin-1-yl)methanone; 3-(N,N-Bis(2-chloroethyl)amino)phenyl piperidin-1-yl ketone; Nitrogen mustard piperidine ketone derivative
EINECS	Contact for details

Quality Control

Our 3-[Bis(2-Chloroethyl)Amino]Phenylpiperidino Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.