Description

2-O,5-o-Diacetyl-1,4:3,6-Dianhydro-D-Mannitol is a specialized, high-purity derivative of isosorbide, a valuable chiral building block derived from renewable resources. This compound is critical for its role as a key intermediate in the synthesis of advanced pharmaceutical actives and fine chemicals, offering precise stereochemistry and functionalization. It is essential for R&D chemists and production units in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel chiral molecules and polymers.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Polymer Chemistry: Serves as a monomer or co-monomer for synthesizing novel, biodegradable polyesters and polycarbonates with enhanced thermal and mechanical properties.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry impacts biological activity.
• Liquid Crystal & Advanced Materials: Acts as a core component in the synthesis of chiral dopants for liquid crystal displays (LCDs) and other functional organic materials.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in asymmetric synthesis to induce high enantioselectivity.
• Cosmetic & Personal Care Ingredients: Potential intermediate for synthesizing novel, skin-compatible emulsifiers and delivery agents.

Basic Information

Item	Detail
Product Name	2-O,5-o-Diacetyl-1,4:3,6-Dianhydro-D-Mannitol
CAS No.	24808-22-8
Molecular Formula	C10H14O6
Molecular Weight	230.21 g/mol
Synonyms	1,4:3,6-Dianhydro-2,5-di-O-acetyl-D-mannitol; Diacetyl Dianhydro Mannitol; Di-O-acetylisosorbide; 2,5-Di-O-acetyl-1,4:3,6-dianhydro-D-mannitol; Isosorbide Diacetate; D-Isosorbide Diacetate; Dianhydromannitol Diacetate
EINECS	Contact for details

Quality Control

Our 2-O,5-o-Diacetyl-1,4:3,6-Dianhydro-D-Mannitol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.