Description

N2,N6-Bis(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester is a highly functionalized, fully protected derivative of the essential amino acid L-lysine, designed for advanced synthetic applications. This compound is crucial for researchers and manufacturers requiring precise control over lysine's reactive amine groups, enabling complex peptide synthesis and derivatization. It is primarily utilized in pharmaceutical R&D, proteomics, and the production of specialized biochemicals where high purity and reliable reactivity are paramount.

Application

• Peptide Synthesis: Serves as a key protected building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Used in the research and development of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Facilitates the site-specific modification of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and the study of post-translational modifications.
• Derivatization Agent: Acts as a silylating reagent for gas chromatography (GC) and mass spectrometry (MS) analysis of amino acids and related compounds.
• Chemical Biology Tool: Provides a versatile handle for introducing lysine analogs into biological systems for mechanistic studies.

Basic Information

Product Name	N2,N6-Bis(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester
CAS No.	24595-69-5
Molecular Formula	C15H36N2O2Si3
Molecular Weight	360.71 g/mol
Synonyms	L-Lysine, N2,N6-bis(trimethylsilyl)-, trimethylsilyl ester; Nε,Nα-Bis(trimethylsilyl)-L-lysine trimethylsilyl ester; Fully protected L-lysine TMS ester; TMS-Lys(TMS)-OTMS; (S)-2,6-Bis(trimethylsilylamino)hexanoic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our N2,N6-Bis(Trimethylsilyl)-L-Lysine Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and ensure stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.