Description

n-[(Benzyloxy)Carbonyl]-L-Isoleucine (4-Pyridylmethyl) Ester is a protected amino acid derivative, specifically an ester of Cbz-L-isoleucine, designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the controlled introduction of the L-isoleucine residue under conditions that prevent racemization, ensuring the stereochemical integrity of the final peptide. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key, protected monomer for the sequential assembly of peptides on resin, particularly where the isoleucine side chain requires specific introduction.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methodologies for constructing complex peptide sequences and natural products.
• Pharmaceutical Intermediate: Acts as a crucial intermediate in the research and development of peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation and Labeling: The reactive ester group and protected amine make it suitable for creating peptide conjugates for diagnostic or targeted drug delivery applications.
• Chemical Biology Research: Employed in the synthesis of peptide probes, enzyme substrates, and inhibitors to study biological pathways and protein function.
• Process Development & Scale-Up: Used in optimizing synthetic routes for the commercial-scale production of peptide therapeutics.

Basic Information

Item	Details
Product Name	n-[(Benzyloxy)Carbonyl]-L-Isoleucine (4-Pyridylmethyl) Ester
CAS No.	23926-75-2
Molecular Formula	C20H24N2O4
Molecular Weight	356.42 g/mol
Synonyms	Cbz-L-Isoleucine 4-Pyridylmethyl Ester; Z-L-Ile-OPic; N-Carbobenzoxy-L-isoleucine 4-pyridylmethyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-methylpentanoic acid 4-(pyridinylmethyl) ester; L-Isoleucine, N-[(phenylmethoxy)carbonyl]-, 4-pyridinylmethyl ester; CBZ-ILE-OPIC; Z-Ile-OPic; Nα-Cbz-L-isoleucine picolyl ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Isoleucine (4-Pyridylmethyl) Ester is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.