Description

n-[(Benzyloxy)Carbonyl]-L-Leucine (4-Pyridylmethyl) Ester is a protected amino acid derivative, specifically a Cbz-Leucine ester, designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the controlled introduction of the leucine amino acid residue, offering enhanced solubility and handling properties during complex synthetic sequences. It is primarily utilized by research institutions and pharmaceutical developers working on novel therapeutic peptides, prodrugs, and bioactive molecules.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Research: Serves as a crucial building block in the development of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Prodrug Design: Used to create ester prodrugs of leucine-containing compounds to improve bioavailability and pharmacokinetic profiles.
• Bioconjugation: Employed in the chemical modification of biomolecules for targeted drug delivery systems and diagnostic agents.
• Chemical Biology: A valuable tool for studying enzyme mechanisms and protein-protein interactions through site-specific incorporation.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic and medicinal chemistry laboratories.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Leucine (4-Pyridylmethyl) Ester
CAS No.	23926-74-1
Molecular Formula	C20H24N2O4
Molecular Weight	356.42 g/mol
Synonyms	N-Carbobenzoxy-L-leucine 4-pyridylmethyl ester; Cbz-L-Leucine 4-Pyridylmethyl Ester; Z-Leu-OPic; Nα-(Benzyloxycarbonyl)-L-leucine 4-(pyridinylmethyl) ester; N-Cbz-L-leucine 4-picolyl ester; (4-Pyridyl)methyl N-[(benzyloxy)carbonyl]-L-leucinate; L-Leucine, N-[(phenylmethoxy)carbonyl]-, 4-pyridinylmethyl ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Leucine (4-Pyridylmethyl) Ester is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and conformity to customer specifications. Our quality system supports cGMP compliance for applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.