Description

tert-Butyl 2-bromo-2-methylpropanoate is a high-purity, versatile chemical building block essential for advanced organic synthesis. Its primary value lies in its role as a protected, activated ester form of 2-bromo-2-methylpropanoic acid, facilitating controlled reactions in complex molecular construction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), advanced intermediates, and novel materials.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of complex drug molecules, particularly those requiring the introduction of tert-butyl ester-protected carboxylic acid groups or bromoalkyl moieties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where its specific reactivity profile is advantageous.
• Polymer Chemistry: Serves as a functional monomer or initiator in controlled radical polymerization processes, such as Atom Transfer Radical Polymerization (ATRP), for creating polymers with precise architectures.
• Peptide & Protein Modification: Employed for the site-specific alkylation or acylation of amino acids, peptides, and proteins in biochemical research.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Utilized in the development of novel organic frameworks, dendrimers, and surface-functionalized materials.

Basic Information

Item	Detail
Product Name	tert-Butyl 2-Bromo-2-methylpropanoate
CAS No.	23877-12-5
Molecular Formula	C8H15BrO2
Molecular Weight	223.11 g/mol
Synonyms	2-Bromo-2-methylpropanoic acid tert-butyl ester; tert-Butyl bromoisobutyrate; 2-Bromo-2-methylpropionic acid tert-butyl ester; Bromoisobutyric acid tert-butyl ester; t-Butyl 2-bromoisobutyrate; BIB; tert-Butyl α-bromoisobutyrate; 2-Bromo-2-methyl-1-oxopropane-1,1-diyl dibutyl ester (common name variant)
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-bromo-2-methylpropanoate is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible results in sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.