Description

Phenyl-Acetic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester is a high-purity, reactive chemical intermediate primarily used as an activated ester for peptide coupling and other amide bond formation reactions. Its value lies in its ability to efficiently introduce the phenylacetyl group under mild conditions, making it a critical reagent for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptides and modified biomolecules.
• Peptide Synthesis: Used as an activated ester reagent in solid-phase and solution-phase peptide coupling methodologies.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and plant growth regulators.
• Bioconjugation: Facilitates the labeling and modification of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Polymer Chemistry: Employed in the synthesis of specialized polyamides and other functional polymers.
• Chemical Biology Probes: Used to create probes for studying enzyme activity and biological pathways.

Basic Information

Product Name	Phenyl-Acetic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester
CAS No.	23776-85-4
Molecular Formula	C12H11NO4
Molecular Weight	233.22 g/mol
Synonyms	N-Hydroxysuccinimide Phenylacetate; Phenylacetic Acid N-Hydroxysuccinimide Ester; NHS-Phenylacetate; Phenylacetic Acid Succinimidyl Ester; 1-[(Phenylacetyl)oxy]-2,5-pyrrolidinedione; 2,5-Dioxopyrrolidin-1-yl phenylacetate; N-Succinimidyl Phenylacetate
EINECS	Contact for details

Quality Control

Our Phenyl-Acetic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.