Description

Triethyl Phosphonobromoacetate is a high-purity organophosphorus reagent, specifically a phosphonate ester, widely recognized for its role as a key Horner-Wadsworth-Emmons (HWE) reagent in organic synthesis. Its primary value lies in enabling the efficient construction of carbon-carbon double bonds, particularly in the synthesis of α,β-unsaturated esters and other complex molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable and high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing olefin linkages in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of complex molecules for crop protection agents and pesticides.
• Advanced Material Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Academic & Industrial R&D: A staple reagent in organic chemistry laboratories for method development and the synthesis of novel compounds.
• Fine Chemical Production: Employed in the multi-step synthesis of flavors, fragrances, and specialty chemicals.
• Wittig-Horner Reaction Reagent: Specifically utilized in the Horner-Wadsworth-Emmons olefination to generate (E)-selective alkenes with high stereochemical control.

Basic Information

Product Name	Triethyl Phosphonobromoacetate
CAS No.	23755-73-9
Molecular Formula	C8H16BrO4P
Molecular Weight	287.09 g/mol
Synonyms	Triethyl (bromoacetoxy)phosphonate; (Bromoacetoxy)phosphonic Acid Triethyl Ester; Triethyl Bromoacetoxyphosphonate; Phosphonoacetic Acid, Bromo-, Triethyl Ester; Triethyl Phosphono(bromoacetate); Ethyl (Diethoxyphosphinyl) Bromoacetate; HWE Reagent (Bromoacetate variant); Bromoacetic Acid Triethyl Phosphonate Ester
EINECS	Contact for details

Quality Control

Our Triethyl Phosphonobromoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.