Description

Methyl-3-Bromopropiolate is a versatile brominated alkyne ester, a key building block in advanced organic synthesis. Its high reactivity, particularly in metal-catalyzed cross-coupling and cycloaddition reactions, makes it invaluable for constructing complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing acetylene or heterocyclic moieties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators requiring specific alkyne functionalization.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with tailored properties.
• Organic Synthesis Building Block: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to introduce acetylene units.
• Click Chemistry: An effective substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating bioconjugation and polymer functionalization.
• Ligand and Catalyst Development: Used in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	Methyl-3-Bromopropiolate
CAS No.	23680-40-2
Molecular Formula	C4H3BrO2
Molecular Weight	162.97 g/mol
Synonyms	Methyl 3-Bromopropiolate; 3-Bromopropiolic Acid Methyl Ester; Methyl β-Bromopropiolate; Propiolic Acid, 3-Bromo-, Methyl Ester; Methyl Bromopropiolate; Bromomethyl Propiolate; Methyl (3-Bromo-2-propynoate)
EINECS	Contact for details

Quality Control

Our Methyl-3-Bromopropiolate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.