Description

1,4-Dioxaspiro[4.5]Decan-8-Ol 4-Methylbenzenesulfonate is a high-value organic intermediate and protecting group reagent, specifically the tosylate derivative of a spirocyclic diol. This compound is critical for synthetic chemists as it provides a stable, activated leaving group for nucleophilic substitution reactions, enabling the controlled functionalization of complex molecular scaffolds. It is primarily utilized in advanced pharmaceutical research, agrochemical synthesis, and the development of specialty materials where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with spirocyclic or complex polycyclic architectures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that require specific stereochemical configurations.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing the 1,4-dioxaspiro[4.5]decan-8-yl moiety into target molecules via SN2 reactions.
• Protecting Group Chemistry: The tosylate group acts as a protective and activatable handle for alcohols in complex, multi-functional molecule synthesis.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Academic & R&D Laboratories: A valuable tool for methodological development and exploring new chemical spaces in university and industrial research settings.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Decan-8-Ol 4-Methylbenzenesulfonate
CAS No.	23511-05-9
Molecular Formula	C16H22O5S
Molecular Weight	326.41 g/mol
Synonyms	8-Hydroxy-1,4-dioxaspiro[4.5]decane 4-methylbenzenesulfonate; 1,4-Dioxaspiro[4.5]decan-8-yl p-toluenesulfonate; Spirocyclic diol tosylate; 8-Tosyloxy-1,4-dioxaspiro[4.5]decane; Cyclohexanone ethylene ketal 8-tosylate; Tosylate of 1,4-dioxaspiro[4.5]decan-8-ol; p-Toluenesulfonic acid 1,4-dioxaspiro[4.5]decan-8-yl ester
EINECS	Contact for details

Quality Control

Our production of 1,4-Dioxaspiro[4.5]Decan-8-Ol 4-Methylbenzenesulfonate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability for your critical synthesis steps. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.