Description

Methyl 2-Bromo-2-Methylpropionate is a versatile brominated ester building block essential for organic synthesis. Its value lies in its highly reactive α-bromoester functionality, which facilitates key carbon-carbon bond-forming reactions and serves as an effective alkylating agent. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing tert-butyl or other branched alkyl groups via nucleophilic substitution or coupling reactions.
• Agrochemical Synthesis: Used in the manufacturing of herbicides, fungicides, and plant growth regulators where its bromine atom acts as a leaving group for further functionalization.
• Polymer Chemistry: Serves as a monomer or chain transfer agent in controlled radical polymerization (e.g., ATRP - Atom Transfer Radical Polymerization) to produce polymers with specific terminal functionalities.
• Organic Synthesis Reagent: Employed in classic reactions such as Reformatsky-type reactions and as an electrophile in alkylations to synthesize α-hydroxy esters, α-amino esters, and other complex organic molecules.
• Ligand and Catalyst Preparation: Utilized for the synthesis of specialized ligands and metal-organic frameworks (MOFs) in catalysis research.
• Flavor and Fragrance Industry: Acts as an intermediate for producing certain ester-based aroma chemicals.

Basic Information

Product Name	Methyl 2-Bromo-2-Methylpropionate
CAS No.	23426-63-3
Molecular Formula	C5H9BrO2
Molecular Weight	181.03 g/mol
Synonyms	Methyl 2-Bromoisobutyrate; 2-Bromo-2-methylpropionic Acid Methyl Ester; Methyl α-Bromoisobutyrate; MBI; Methyl 2-Bromo-2-methylpropanoate; 2-Bromoisobutyric Acid Methyl Ester; Methyl 2-Bromodimethylacetate; Methyl Bromoisobutyrate
EINECS	245-648-4

Quality Control

Our Methyl 2-Bromo-2-Methylpropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.450 - 1.455
Density (g/mL, 20°C)	1.40 - 1.45

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.