Description

3-Azido-3-Deoxy-1,2-o-Isopropylidene-α-D-Ribofuranose is a key protected ribofuranose derivative, serving as a versatile chiral synthon and nucleoside precursor. Its value lies in the strategic introduction of an azido group at the 3'-position, enabling further functionalization via click chemistry or reduction to an amine. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of modified nucleosides, antiviral agents, and carbohydrate-based probes.

Application

• Nucleoside & Nucleotide Analog Synthesis: A critical intermediate for constructing modified nucleosides with potential antiviral or anticancer activity.
• Carbohydrate Chemistry & Glycobiology: Used as a building block for synthesizing complex oligosaccharides, glycoconjugates, and glycomimetics.
• Pharmaceutical Intermediate: Serves as a chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: The azido group facilitates site-specific labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for creating diagnostic or imaging probes.
• Antiviral Research: Particularly relevant in the development of nucleoside reverse transcriptase inhibitors and other antiviral compounds.
• Chemical Biology Tool: Enables the study of biological processes through metabolic labeling and bioorthogonal chemistry strategies.

Basic Information

Product Name	3-Azido-3-Deoxy-1,2-o-Isopropylidene-α-D-Ribofuranose
CAS No.	23345-80-4
Molecular Formula	C8H13N3O4
Molecular Weight	215.21 g/mol
Synonyms	1,2-O-Isopropylidene-3-azido-3-deoxy-α-D-ribofuranose; 3-Azido-1,2-O-isopropylidene-3-deoxy-α-D-ribofuranose; 3-Azido-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose; 3-Azido-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-allofuranose (related protected form); 3-Azido-3-deoxy-1,2-O-(1-methylethylidene)-α-D-ribofuranose; α-D-Ribofuranose, 3-azido-3-deoxy-1,2-O-(1-methylethylidene)-; 3-Azido-3-deoxy-1,2-O-isopropylidene-D-ribofuranose
EINECS	Contact for details

Quality Control

Our 3-Azido-3-Deoxy-1,2-o-Isopropylidene-α-D-Ribofuranose is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.