Description

Probucol is a synthetic lipophilic antioxidant compound with significant pharmacological activity. It is valued for its potent ability to inhibit the oxidation of low-density lipoprotein (LDL) cholesterol, a key factor in the development of atherosclerosis. This makes it a critical intermediate and active pharmaceutical ingredient (API) for research and development in the cardiovascular and metabolic disease sectors. Global pharmaceutical manufacturers and advanced research institutions rely on high-purity Probucol CAS NO 23288-49-5 for developing innovative therapeutic formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulations targeting hypercholesterolemia and atherosclerosis.
• Cardiovascular Disease Research: Key compound in preclinical and clinical studies investigating LDL oxidation and plaque stabilization.
• Metabolic Syndrome Studies: Utilized in research exploring the compound's effects on lipid metabolism and insulin sensitivity.
• Antioxidant Mechanism Research: Serves as a model compound for studying the biological effects of lipophilic antioxidants in cellular systems.
• Reference Standard: Used in analytical laboratories as a high-purity standard for quality control and method development (HPLC, GC).
• Formulation Development: Employed in the development of solid dosage forms (tablets, capsules) and novel drug delivery systems.

Basic Information

Product Name	Probucol
CAS No.	23288-49-5
Molecular Formula	C31H48O2S2
Molecular Weight	516.85 g/mol
Synonyms	4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]; Biphenabid; Lesterol; Lorelco; Bisphenol derivative; DH-581; 2,2'-[Isopropylidenebis(thio)]bis[4,6-di-tert-butylphenol]; 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
EINECS	245-552-1

Quality Control

Our Probucol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing results from tests such as HPLC assay, related substances, residual solvents, and heavy metals are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.