Description

2,2,2-Trifluoroethyl Trichloromethanesulfonate is a specialized organosulfur reagent of significant interest in advanced synthetic chemistry. Its value lies in its dual functionality as a powerful trifluoromethylating and sulfonylating agent, enabling the efficient introduction of fluorine-containing groups into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients with enhanced properties such as metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that benefit from the unique properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or modifying agent in the development of specialty polymers and coatings with specific chemical resistance or surface properties.
• Fluorination Reagent: Employed in organic synthesis for the efficient transfer of the -CF3 group to arenes, heterocycles, and other complex organic scaffolds.
• Sulfonate Ester Chemistry: Acts as a reactive sulfonylating agent for alcohols and amines in protecting group strategies or to create sulfonate esters for further functionalization.
• Ligand and Catalyst Development: Utilized in the preparation of novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,2,2-Trifluoroethyl Trichloromethanesulfonate
CAS No.	23199-56-6
Molecular Formula	C3H2Cl3F3O3S
Molecular Weight	281.46 g/mol
Synonyms	Trichloromethanesulfonic Acid 2,2,2-Trifluoroethyl Ester; 2,2,2-Trifluoroethyl Trichloromethanesulphonate; Perchloromethylsulfonic Acid Trifluoroethyl Ester; Trifluoroethyl Trichloromethanesulfonate; (2,2,2-Trifluoroethoxy)sulfonyl Trichloromethane; CF3CH2OSO2CCl3
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethyl Trichloromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.75 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.