Description

2-Bromo-4-Chloropyridine is a versatile halogenated pyridine derivative that serves as a crucial building block in advanced organic synthesis. Its value lies in its dual reactive sites, which allow for selective functionalization, making it indispensable for constructing complex molecular architectures. This high-purity intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized pyridine-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Nucleophilic Aromatic Substitution: The bromine and chlorine atoms offer distinct reactivity for sequential substitution, enabling diverse derivatization.

Basic Information

Item	Details
Product Name	2-Bromo-4-Chloropyridine
CAS No.	22918-01-0
Molecular Formula	C5H3BrClN
Molecular Weight	192.44 g/mol
Synonyms	4-Chloro-2-bromopyridine; 2-Bromo-4-chloropyridine; 4-Chloro-2-bromo-pyridine; Pyridine, 2-bromo-4-chloro-; 22918-01-0; 2-Br-4-Cl-Pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets the stringent requirements of synthesis applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.