Description

Methyl L-Histidinate Hydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and biochemical research. This compound serves as a critical building block, offering a protected histidine side chain to prevent unwanted reactions during complex molecular assembly. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic laboratories developing novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of peptides containing histidine residues, particularly for drug discovery and development.
• Pharmaceutical Research: Used in the development of enzyme inhibitors, receptor agonists/antagonists, and other bioactive molecules targeting histidine-related pathways.
• Bioconjugation: Acts as a precursor for creating histidine-tagged molecules used in protein purification and labeling techniques.
• Biochemical Studies: Employed in research to study metal-binding properties, enzyme mechanisms, and protein-protein interactions where histidine plays a functional role.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing and research.

Basic Information

Item	Details
Product Name	Methyl L-Histidinate Hydrochloride
CAS No.	22888-60-4
Molecular Formula	C7H12N3O2 • HCl
Molecular Weight	221.65 g/mol
Synonyms	L-Histidine methyl ester hydrochloride; Methyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate hydrochloride; Histidine methyl ester HCl; H-His-OMe • HCl; Methyl L-histidinate HCl; (S)-Methyl 2-amino-3-(1H-imidazol-5-yl)propanoate hydrochloride; Methyl 2-amino-3-(1H-imidazol-4-yl)propionate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl L-Histidinate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: +10.0° to +15.0° (c=1 in H₂O)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.