Description

2,3,4,6-Tetra-o-Acetyl-A-D-Mannopyranose is a key acetylated monosaccharide derivative, serving as a crucial protected intermediate in synthetic carbohydrate chemistry. Its primary value lies in enabling the controlled synthesis of complex oligosaccharides, glycoconjugates, and other bioactive molecules where the mannose moiety is essential. This high-purity building block is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries, particularly for developing glycoprotein-based therapeutics, vaccines, and diagnostic reagents.

Application

• Glycosylation Reagent: A fundamental building block for the chemical and enzymatic synthesis of complex oligosaccharides and glycans.
• Pharmaceutical Intermediate: Used in the research and production of carbohydrate-based drugs, including antiviral agents, anti-inflammatory compounds, and cancer therapeutics.
• Glycoconjugate Synthesis: Critical for creating glycoproteins, glycolipids, and neoglycoconjugates for vaccine development and targeted drug delivery systems.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving glycosidases and glycosyltransferases.
• Carbohydrate Chemistry Standard: Used as a reference standard in analytical laboratories for method development and quality control of carbohydrate APIs.
• Fine Chemical Synthesis: An intermediate for synthesizing specialty surfactants, chiral ligands, and other advanced materials with specific stereochemistry.

Basic Information

Product Name	2,3,4,6-Tetra-o-Acetyl-A-D-Mannopyranose
CAS No.	22860-22-6
Molecular Formula	C14H20O10
Molecular Weight	348.30 g/mol
Synonyms	1,2,3,4,6-Penta-O-acetyl-α-D-mannopyranose; α-D-Mannopyranose, 1,2,3,4,6-pentaacetate; Penta-O-acetyl-α-D-mannopyranose; Acetylated D-Mannose; α-D-Mannose pentaacetate; 2,3,4,6-Tetra-O-acetyl-α-D-mannopyranosyl chloride precursor; Mannose pentaacetate, α-form
EINECS	245-274-5

Quality Control

Our 2,3,4,6-Tetra-o-Acetyl-A-D-Mannopyranose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and GMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization, supporting its use in advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	+49.0° to +53.0° (c=1 in CHCl₃)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.