Description

4-Trimethylsilyl-Thioanisole is a specialized organosilicon compound featuring a trimethylsilyl group attached to a thioanisole core, making it a valuable silylating agent and synthetic intermediate. Its primary value lies in its ability to act as a versatile protecting group and a precursor in the synthesis of complex organic molecules, particularly in pharmaceutical and advanced material chemistry. This high-purity reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable building blocks for heterocyclic and sulfur-containing compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfur heterocycles.
• Silylating Agent: Used to introduce the trimethylsilyl (TMS) protecting group onto alcohols, phenols, and other nucleophiles in multi-step organic syntheses.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents.
• Material Science Research: Precursor for the development of novel silicon-based polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Kumada, Negishi) to form new carbon-carbon bonds.
• Laboratory Reagent: Used in academic and industrial R&D for method development and the exploration of new synthetic pathways.

Basic Information

Product Name	4-Trimethylsilyl-Thioanisole
CAS No.	22515-25-9
Molecular Formula	C10H16SSi
Molecular Weight	196.39 g/mol
Synonyms	1-(Trimethylsilyl)-4-(methylthio)benzene; p-(Methylthio)phenyltrimethylsilane; 4-(Methylthio)phenyltrimethylsilane; (4-Methylsulfanylphenyl)trimethylsilane; Trimethyl(4-methylthiophenyl)silane; 4-(Trimethylsilyl)thioanisole; TMS-Thioanisole
EINECS	Contact for details

Quality Control

Our 4-Trimethylsilyl-Thioanisole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including GC, HPLC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.