Description

Benfotiamine is a synthetic, lipid-soluble derivative of thiamine (Vitamin B1) with superior bioavailability. This compound is critical for addressing thiamine deficiency and supporting advanced nutritional and therapeutic formulations. It is primarily sought by manufacturers in the pharmaceutical, nutraceutical, and dietary supplement industries for its enhanced stability and absorption profile compared to standard thiamine salts.

Application

• Pharmaceutical Active Ingredient (API): Used in prescription and over-the-counter medications for diabetic neuropathy, Alzheimer's disease research, and other conditions linked to thiamine deficiency.
• Dietary Supplement Formulation: A key component in high-potency B-complex capsules, tablets, and softgels targeting metabolic health and nerve function.
• Nutraceutical and Functional Food Fortification: Incorporated into specialized nutritional powders, drink mixes, and medical foods requiring stable, bioavailable thiamine.
• Clinical Research and Reference Standard: Serves as a pure compound for biochemical research, pharmacokinetic studies, and analytical method development.
• Veterinary Nutrition: Used in premium pet health supplements and animal feed additives to support neurological and metabolic wellness.

Basic Information

Product Name	Benfotiamine
CAS No.	22457-89-2
Molecular Formula	C19H23N4O6PS
Molecular Weight	466.45 g/mol
Synonyms	S-Benzoylthiamine O-monophosphate; Benfotiamin; BFT; O-Monophosphothiamine S-benzoyl disulfide; Thiamine Monophosphate Disulfide, S-Benzoyl Derivative; ((4-Amino-2-methyl-5-pyrimidinyl)methyl)formylamino)methyl S-benzoyl phosphorothioate; Vitamin B1 Monophosphate Disulfide S-Benzoyl; 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium S-benzoate monophosphate
EINECS	Contact for details

Quality Control

Our Benfotiamine is manufactured under strict quality systems. We offer grades suitable for pharmaceutical and nutraceutical applications, with testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting key parameters such as assay, related substances, and residual solvents are provided with every batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.