Description

(R)-2-Amino-3-o-Tolyl-Propionic Acid Ethyl Ester is a chiral, non-proteinogenic amino acid derivative of significant synthetic utility. This compound serves as a crucial building block in the synthesis of complex molecules, particularly in the pharmaceutical sector where stereochemical purity is paramount. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in neurological and metabolic disorder therapeutics.
• Peptidomimetics Synthesis: Used in the construction of peptide analogs and peptidomimetics to enhance stability, bioavailability, and biological activity.
• Agrochemical Research: Serves as a precursor in the development of new chiral herbicides, fungicides, and plant growth regulators.
• Asymmetric Catalysis: Employed as a ligand or a substrate in asymmetric synthesis to induce chirality in target molecules.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry within university and corporate laboratories.

Basic Information

Product Name	(R)-2-Amino-3-o-Tolyl-Propionic Acid Ethyl Ester
CAS No.	22435-99-0
Molecular Formula	C₁₂H₁₇NO₂
Molecular Weight	207.27 g/mol
Synonyms	(R)-2-Amino-3-(2-methylphenyl)propanoic acid ethyl ester; Ethyl (R)-2-amino-3-(o-tolyl)propanoate; (R)-Ethyl 2-amino-3-(2-methylphenyl)propionate; D-2-Amino-3-o-tolylpropionic acid ethyl ester; (R)-α-Amino-o-tolylpropionic acid ethyl ester; (R)-3-(2-Methylphenyl)alanine ethyl ester; (R)-Homo(2-methylphenyl)alanine ethyl ester
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-3-o-Tolyl-Propionic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (e.e.), and impurity profiles are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.