Description

(R)-(+)-Seconal CAS NO 22328-94-5 is a high-purity enantiomer of the barbiturate derivative secobarbital, distinguished by its specific (R)-(+) stereochemistry. This precise chiral configuration is critical for research and development in neuropharmacology and medicinal chemistry, where stereoselective activity is paramount. It serves as an essential reference standard and building block for pharmaceutical researchers, analytical laboratories, and academic institutions investigating central nervous system (CNS) agents, receptor binding studies, and metabolic pathways.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of secobarbital in drug testing, forensic analysis, and quality control laboratories.
• Medicinal Chemistry Research: Serves as a key chiral intermediate or precursor in the synthesis and development of novel CNS-active compounds and stereospecific pharmaceuticals.
• Pharmacological Studies: Employed in in vitro and in vivo studies to investigate the mechanism of action, pharmacokinetics, and metabolic profile of barbiturate drugs.
• Analytical Method Development: Essential for developing and validating chromatographic methods (HPLC, GC) and spectroscopic assays for barbiturate detection and quantification.
• Academic & Institutional Research: Used in university and institutional labs for teaching and advanced research in neurochemistry, toxicology, and drug design.
• Impurity Profiling: Acts as a marker for identifying and quantifying stereoisomeric impurities in bulk secobarbital or related pharmaceutical formulations.

Basic Information

Product Name	(R)-(+)-Seconal
CAS No.	22328-94-5
Molecular Formula	C12H18N2O3
Molecular Weight	238.28 g/mol
Synonyms	(R)-Secobarbital; (R)-(+)-Secobarbital; D-Seconal; (5R)-5-(1-Methylbutyl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione; (R)-5-Allyl-5-(1-methylbutyl)barbituric acid; (R)-Seconal; (R)-Quinalbarbitone; (R)-Meballymal
EINECS	Contact for details

Quality Control

Our (R)-(+)-Seconal is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.