Description

[R,(-)]-D-Glycerol 1-[Carbonic Acid (2,2,2-Trichloroethyl)] Ester is a specialized chiral glycerol derivative, serving as a crucial protected intermediate in advanced organic synthesis. Its core value lies in enabling the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. This high-purity compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over molecular architecture.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of chiral drugs, prodrugs, and active pharmaceutical ingredients (APIs), particularly in nucleoside and carbohydrate chemistry.
• Chiral Auxiliary/Reagent: Used in asymmetric synthesis to induce chirality in target molecules, leveraging its defined stereochemistry.
• Protecting Group Chemistry: The 2,2,2-trichloroethyl (TCE) carbonate moiety acts as a robust protecting group for primary alcohols, which can be removed under specific, mild conditions.
• Biochemical Research: Employed in the preparation of modified lipids, phospholipids, and other biologically active glycerol derivatives for mechanistic and metabolic studies.
• Agrochemical Synthesis: Intermediate in the production of chiral pesticides, herbicides, and plant growth regulators.
• Material Science Precursor: Used in the development of specialty polymers and functional materials with tailored properties.

Basic Information

Product Name	[R,(-)]-D-Glycerol 1-[Carbonic Acid (2,2,2-Trichloroethyl)] Ester
CAS No.	22202-35-3
Molecular Formula	C6H9Cl3O5
Molecular Weight	275.49 g/mol
Synonyms	(R)-(-)-1,2-Isopropylidene-3-O-(2,2,2-trichloroethoxycarbonyl)glycerol; (R)-1,2-O-Isopropylidene-3-O-[(2,2,2-trichloroethoxy)carbonyl]glycerol; D-(-)-1,2-Isopropylidene-3-O-(2,2,2-trichloroethoxycarbonyl)glycerol; (R)-1,2-O-Isopropylidene-3-O-(trichloroethoxycarbonyl)glycerol; (R)-TCE-Protected Glycerol Acetonide; (R)-3-O-(2,2,2-Trichloroethoxycarbonyl)-1,2-O-isopropylidene-sn-glycerol; (R)-Glycerol 1,2-acetonide 3-(2,2,2-trichloroethyl carbonate)
EINECS	Contact for details

Quality Control

Our [R,(-)]-D-Glycerol 1-[Carbonic Acid (2,2,2-Trichloroethyl)] Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and production use. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.