Description

Tetrahydro-2-[Bis(2-Chloroethyl)Amino]-5-Methyl-2H-1,3,2-Oxazaphosphorine 2-Oxide is a key nitrogen mustard derivative and a critical intermediate in the synthesis of complex pharmaceutical agents. This compound is valued for its precise chemical structure, which is essential for producing targeted therapeutic molecules in oncology and immunology research. It is primarily required by advanced pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in developing novel alkylating agents and prodrugs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of specialized chemotherapeutic agents and prodrugs.
• Oncology Research: Used in the development and study of novel nitrogen mustard-based alkylating compounds for cancer therapy.
• Immunosuppressant Synthesis: Serves as a precursor in the creation of experimental immunosuppressive drugs.
• Bioconjugation Chemistry: Employed in the design of antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Fine Chemical Manufacturing: Utilized in multi-step organic synthesis for producing high-value, complex molecules.
• Academic & Industrial R&D: A key reagent for investigating structure-activity relationships (SAR) in medicinal chemistry programs.

Basic Information

Product Name	Tetrahydro-2-[Bis(2-Chloroethyl)Amino]-5-Methyl-2H-1,3,2-Oxazaphosphorine 2-Oxide
CAS No.	22089-26-5
Molecular Formula	C8H17Cl2N2O2P
Molecular Weight	275.11 g/mol
Synonyms	5-Methylcyclophosphamide; NSC-51325; 2-[Bis(2-chloroethyl)amino]tetrahydro-5-methyl-2H-1,3,2-oxazaphosphorine 2-oxide; 4-Methylcyclophosphamide; 4-Methyl-cyclophosphamide; 5-Methyl-cyclophosphamide; Cyclophosphamide Impurity F (EP); Cyclophosphamide Related Compound F (USP)
EINECS	244-783-8

Quality Control

Our Tetrahydro-2-[Bis(2-Chloroethyl)Amino]-5-Methyl-2H-1,3,2-Oxazaphosphorine 2-Oxide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or custom client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued lighting or in amber glass containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.