Description

Diphyllin is a naturally occurring lignan compound, recognized for its significant biological activity and potential as a lead structure in pharmaceutical research. Its core value lies in its potent inhibitory effects on specific enzymes and biological pathways, making it a valuable tool for scientific discovery and development. This compound is primarily needed by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on antiviral, anticancer, and anti-inflammatory therapeutic strategies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of novel therapeutics.
• Antiviral Agent Studies: Investigated for its activity against various viruses, including HIV and SARS-CoV-2, due to its ability to inhibit viral entry and replication.
• Oncology Research: Explored for its anti-proliferative and pro-apoptotic effects on various cancer cell lines, positioning it as a candidate for anticancer drug development.
• V-ATPase Inhibition: Used as a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase), a crucial enzyme target in cell biology and disease research.
• Biochemical Tool Compound: Employed in laboratory settings to study intracellular pH regulation, autophagy, and protein trafficking pathways.
• Natural Product Chemistry: Serves as a benchmark compound for the isolation, identification, and synthesis of related lignan derivatives.

Basic Information

Product Name	Diphyllin
CAS No.	22055-22-7
Molecular Formula	C22H18O8
Molecular Weight	410.37 g/mol
Synonyms	5,8-Dihydroxy-2,7-bis(4-hydroxyphenyl)naphtho[2,3-b]furan-4,9-dione; 4,9-Dihydroxy-2,7-bis(4-hydroxyphenyl)naphtho[2,3-b]furan-5,8-dione; (-)-Diphyllin; NSC 330836; Arylnaphthalide lignan
EINECS	Contact for details

Quality Control

Our Diphyllin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.