Description

Estradiol 3-Valerate is a synthetic, long-acting ester derivative of the natural estrogen, estradiol. This compound is a critical active pharmaceutical ingredient (API) valued for its enhanced stability and prolonged duration of action compared to the parent hormone. It is primarily required by the pharmaceutical industry for the formulation of hormone replacement therapies (HRT) and other steroidal medications, serving a vital role in global healthcare.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable hormone replacement therapies for managing menopausal symptoms.
• Hormone Replacement Therapy (HRT): Formulation of long-acting depot injections for the treatment of estrogen deficiency.
• Veterinary Medicine: Used in veterinary pharmaceuticals for reproductive management in livestock and companion animals.
• Research & Development: Serves as a key reference standard and intermediate in endocrine and metabolic research within academic and industrial laboratories.
• Contraceptive Formulations: A component in certain combined hormonal contraceptive products.
• Oncology Supportive Care: Utilized in certain protocols for managing hormone-sensitive conditions.

Basic Information

Product Name	Estradiol 3-Valerate
CAS No.	21881-45-8
Molecular Formula	C23H32O3
Molecular Weight	356.50 g/mol
Synonyms	Estradiol Valerate; Estradiol 17-Valerate; Oestradiol Valerate; Delestrogen; Progynon Depot; 17β-Estradiol 17-Valerate; Estr-1,3,5(10)-triene-3,17β-diol 17-valerate; (17β)-3,17-Dihydroxyestra-1,3,5(10)-trien-3-yl pentanoate
EINECS	244-638-1

Quality Control

Our Estradiol 3-Valerate is manufactured under strict quality management systems. It is tested to meet high-purity standards relevant for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA), detailing identity, purity, and impurity profiles, is provided with every batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+48° to +52° (c=1 in dioxane)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.