Description

D-(+)-α-Methylbenzylisocyanide is a chiral isocyanide derivative, a versatile and valuable building block in synthetic organic chemistry. Its primary value lies in its role as a key ligand in transition metal catalysis and as a crucial component in multicomponent reactions, enabling the efficient synthesis of complex, nitrogen-containing heterocycles. This high-purity chiral reagent is essential for research and development in pharmaceutical chemistry, agrochemical discovery, and advanced material science, where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate Synthesis: A critical chiral ligand and reactant for constructing complex, bioactive molecules and heterocyclic scaffolds in drug discovery and development.
• Catalysis Research: Used as a specialized ligand in palladium-catalyzed cross-coupling reactions and other transition metal-catalyzed processes to improve selectivity and yield.
• Multicomponent Reactions (MCRs): A fundamental component in Passerini and Ugi-type reactions for the rapid, one-pot generation of diverse compound libraries.
• Agrochemical Development: Employed in the synthesis of novel, chiral active ingredients for crop protection agents.
• Material Science Research: Serves as a precursor for the development of functional polymers and advanced organic materials with tailored properties.
• Academic & Industrial R&D: A standard reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	D-(+)-α-Methylbenzylisocyanide
CAS No.	21872-33-3
Molecular Formula	C9H9N
Molecular Weight	131.18 g/mol
Synonyms	(R)-(+)-α-Methylbenzyl isocyanide; (R)-1-Phenylethyl isocyanide; (R)-(+)-1-Phenylethyl isocyanide; D-α-Methylbenzyl isocyanide; (R)-1-Isocyano-1-phenylethane; (R)-(+)-1-Isocyano-1-phenylethane; (R)-1-Phenylethylisonitrile; (R)-(+)-1-Phenylethylisonitrile
EINECS	Contact for details

Quality Control

Every batch of D-(+)-α-Methylbenzylisocyanide is manufactured and tested under strict quality management protocols to ensure high chemical purity and chiral integrity. Our products undergo rigorous quality testing, including chiral purity analysis by HPLC, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA), detailing purity, specific rotation, and identity, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Specific Rotation [α]20/D	+80° to +90° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.