Description

(S)-(-)-α-Methylbenzyl Isocyanide is a chiral isocyanide building block of significant importance in asymmetric synthesis. This compound matters as a versatile reagent for the construction of complex, stereodefined molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development scientists working on the synthesis of chiral ligands, natural products, and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Synthesis: A key chiral building block for the Passerini and Ugi multicomponent reactions, enabling the rapid generation of stereogenic centers.
• Pharmaceutical Intermediates: Used in the research and development of chiral drug candidates, including potential therapeutics for central nervous system (CNS) disorders and oncology.
• Catalyst & Ligand Development: Serves as a precursor for the synthesis of novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in creating chiral active ingredients for herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Exploration of its use in the synthesis of chiral polymers and functional materials with specific optical properties.
• Academic & Industrial R&D: A fundamental reagent in methodological studies for developing new chiral isocyanide-based reactions.

Basic Information

Product Name	(S)-(-)-α-Methylbenzyl Isocyanide
CAS No.	21872-32-2
Molecular Formula	C9H9N
Molecular Weight	131.18 g/mol
Synonyms	(S)-(-)-1-Phenylethyl isocyanide; (S)-1-Phenylethyl isocyanide; (S)-α-Methylbenzyl isocyanide; (S)-(-)-1-Isocyano-1-phenylethane; (S)-1-Isocyanoethylbenzene; (S)-(-)-α-Methylbenzyl isonitrile; (S)-1-Phenylethyl isonitrile
EINECS	Contact for details

Quality Control

Our (S)-(-)-α-Methylbenzyl Isocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. Due to its sensitivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.