Description

Alanine, n-Hydroxy-, 1,1-Dimethylethyl Ester (9Ci) is a protected amino acid derivative, specifically a tert-butyl ester of N-hydroxyalanine, which serves as a crucial building block in advanced organic synthesis. This compound is valued for its role in introducing the N-hydroxy functionality into peptide backbones and complex molecules, enabling the development of novel enzyme inhibitors and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics research, and the synthesis of peptidomimetics and hydroxamate-based drug candidates.

Application

• Pharmaceutical Intermediates: Key synthon for the production of hydroxamic acid derivatives, which are potent inhibitors of metalloenzymes like histone deacetylases (HDACs) and matrix metalloproteinases (MMPs).
• Peptide Chemistry: Used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis to incorporate N-hydroxyalanine residues.
• Medicinal Chemistry Research: Serves as a precursor in the design and synthesis of novel drug candidates targeting cancer, inflammation, and neurodegenerative diseases.
• Chemical Biology Probes: Utilized in the development of activity-based probes and affinity labels for studying enzyme function and protein-protein interactions.
• Agrochemical Synthesis: Intermediate in the research and development of new herbicides and plant growth regulators with novel modes of action.
• Chelating Agent Precursor: Starting material for synthesizing specialized chelators and ligands for metal catalysis and separation processes.

Basic Information

Product Name	Alanine, n-Hydroxy-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	21653-09-8
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	N-Hydroxyalanine tert-Butyl Ester; tert-Butyl N-Hydroxyalaninate; 2-(tert-Butoxycarbonylamino)-2-hydroxypropanoic Acid (tautomer); (2R/S)-2-[(tert-Butoxycarbonyl)amino]-2-hydroxypropanoic Acid; Boc-NH-OH-Ala-OtBu; Alanine, N-hydroxy-, 1,1-dimethylethyl ester; N-Boc-N-hydroxyalanine tert-butyl ester
EINECS	Contact for details

Quality Control

Our Alanine, n-Hydroxy-, 1,1-Dimethylethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.