Description

(R)-(+)-Pentobarbital Sodium is the sodium salt of the dextrorotatory enantiomer of pentobarbital, a short-acting barbiturate derivative. This high-purity chiral compound is critical for research requiring stereochemical specificity, particularly in neurological and pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and specialized chemical manufacturers focused on controlled substance synthesis.

Application

• Pharmacological Reference Standard: Used as a certified analytical standard for method development, validation, and quality control in pharmaceutical testing.
• Neuroscience Research: Employed in preclinical studies to investigate the mechanisms of action, metabolism, and stereoselective effects of barbiturates on the GABAA receptor.
• Veterinary Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of specialized veterinary anesthetics and euthanasia solutions.
• Forensic Analysis: Acts as a qualitative and quantitative standard in forensic toxicology for the identification and measurement of barbiturates in biological samples.
• Metabolic Pathway Studies: Utilized in research to map the enantioselective metabolic pathways and pharmacokinetics of pentobarbital.

Basic Information

Product Name	(R)-(+)-Pentobarbital Sodium
CAS No.	21642-83-1
Molecular Formula	C11H17N2NaO3
Molecular Weight	248.26 g/mol
Synonyms	(R)-(+)-Nembutal Sodium; (R)-5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt; Dextro-Pentobarbital Sodium; (+)-Pentobarbital Sodium; Sodium (R)-5-ethyl-5-(1-methylbutyl)barbiturate; (R)-Pentobarbital Sodium salt; (2R)-5-Ethyl-5-(pentan-2-yl)-1,3-diazinane-2,4,6-trione sodium salt
EINECS	Contact for details

Quality Control

Our (R)-(+)-Pentobarbital Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting full specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.