Description

S-(-)-Pentobarbital Sodium is the sodium salt of the S-enantiomer of pentobarbital, a short-acting barbiturate derivative. This specific stereoisomer is of significant interest in advanced pharmacological research and development due to its distinct biological activity profile. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and specialized chemical manufacturers requiring high-purity enantiomeric compounds for precise studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, GC-MS) for quality control and regulatory testing of pharmaceutical products.
• Biomedical Research: Serves as a critical reagent in neuropharmacology and anesthesiology research to study GABAA receptor interactions, sedation mechanisms, and stereoselective drug metabolism.
• Veterinary Medicine Development: Employed in the formulation and testing of euthanasia solutions and anesthetic agents for animal use, where specific enantiomeric purity is required.
• Forensic Analysis: Acts as a certified reference material (CRM) in toxicological assays for the accurate identification and quantification of barbiturates in biological samples.
• Chemical Synthesis: Used as a chiral building block or intermediate in the synthesis of more complex, stereospecific pharmaceutical compounds.

Basic Information

Product Name	S-(-)-Pentobarbital Sodium
CAS No.	21642-82-0
Molecular Formula	C11H17N2NaO3
Molecular Weight	248.26 g/mol
Synonyms	(S)-(-)-Pentobarbital Sodium Salt; (-)-Pentobarbital Sodium; S-(-)-Nembutal Sodium; (S)-5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione sodium salt; Sodium (S)-(-)-pentobarbital; S-(-)-Sodium pentobarbital; 1H,3H,5H-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, sodium salt, (S)-; NSC 74019
EINECS	Contact for details

Quality Control

Our S-(-)-Pentobarbital Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) providing results for identity, purity (by HPLC), chiral excess, residual solvents, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.